Study of the effects of therapeutic lasers at the molecular and cellular level

Low-power lasers (light amplification by stimulated emission of radiation) and LEDs (light-emitting diodes) have been used to treat various diseases due to their photobiostimulatory effects, which depend on the dose, dose rate, and photon energy of the absorbed radiation. However, the molecular and cellular effects, as well as the potential adverse effects of these non-ionizing radiations, remain poorly understood or underexplored. Therefore, obtaining experimental data on the molecular and cellular responses to these radiations is crucial for improving the safety and effectiveness of therapeutic protocols based on low-power lasers and light-emitting diodes (LEDs). This research project aims to evaluate cell viability, free radical production, gene expression related to DNA damage repair mechanisms, and genomic and telomeric stability in cell cultures and tissues of Wistar rats exposed to therapeutic low-power lasers and LEDs. The results obtained will provide scientific evidence to support clinical protocols and help define appropriate dosimetry, ensuring the use of safe doses in laser and LED-based therapeutic procedures.

Participating Faculty Members:

• Adenilson De Souza Da Fonseca
• André Luiz Mencalha
• Patricia De Albuquerque Garcia Redondo