Epigenetics and gene expression related to DNA repair pathways, tumor hypoxia, and resistance phenotypes in cancer cells

This project explores the epigenetic regulation of HIF1-α and its role in the tumor microenvironment and therapy resistance. The central hypothesis is that epigenetic alterationsmodulate gene expression in hypoxia and DNA repair pathways, contributing to a resistant tumor phenotype. Using both in silico and experimental approaches, the study aims to identify HIF1-α target genes, assess promoter methylation islands, and analyze gene expression under demethylating agents and hypoxia-like conditions. This integrative approach helps elucidate molecular mechanisms of tumor aggressiveness and paves the way for novel cancer treatment strategies.

Participating faculty:
Andre Luiz Mencalha

Funding sources:

• CONS NAC DE DESENVOLVIMENTO CIENTIFICO E TECNOLOGICO - (BOLSA de Iniciação Científica - PIBIC)
• FUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO - (Edital FAPERJ N°20/2023 - PROGRAMA CIENTISTA DO NOSSO ESTADO)
• FUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIRO - (Cientista do Nosso Estado)